The purpose of this BPG is to include evidence-based recommendations for nurses, organizations and health systems to foster nurses’ ability to maintain, advance and strengthen professional practice in the context of a digital health environment. Broadly, this guideline will cover: (1) the skills and competencies required by front-line clinical nurses to ensure safe, quality, person-centred and compassionate clinical care through therapeutic relationships in a digital health environment; (2) the skills and competencies of nurses to engage in the design, development and evaluation of the digital health environment; and (3) the skills and competencies of nurse leaders in all domains (clinical practice, administration, education, policy and research) to support the interface between nursing clinical practice and technology.