This new best practice guideline (BPG) is titled Promoting 2SLGBTQI+ Health Equity. The purpose of this BPG is to provide nurses and other members of the interprofessional team with evidence-based recommendations on foundational, inclusive and affirming care practices for Two-Spirit, lesbian, gay, bisexual, trans, queer, intersex, and additional (2SLGBTQI+) people. This BPG is also to be used to enhance the safety of health-service organizations, schools and academic organizations for 2SLGBTQI+ communities through the adoption of evidence-based practices.