The purpose of this Guideline is to provide evidence-based recommendations that promote and sustain the undergraduate nursing student’s application of knowledge to practice in a variety of clinical learning environments. The Guideline explores the relationships among and between students and nursing educators, nursing staff, preceptors, and diverse health-care team members, and it considers their influence on the quality of practice education, professional socialization, and nursing excellence. The recommendations will help nurse educators, preceptors, staff nurses, and other members of the interprofessional health-care team better understand how to foster and support effective teaching and learning strategies in a variety of practice settings, as well as how they can advocate for change. The context of the Guideline is framed within the system of interaction amongst educational institutions, service agencies and policy-makers, with specific recommendations for each entity. However, educational institutions and service agencies involved in implementing this Guideline will find that many of the recommendations are applicable to both entities and require collaborative efforts between the two.